Mutant woman feels no pain and heals without scarring
Woman said she would be elated if any research into her own genetics could help other people suffering
(Web Desk) – 71-year-old Scottish woman literally feels no pain whatsoever and heals at superhuman rate moving the Marvel and DC movies into non-fiction category.
UK researchers discovered that Jo Cameron, the mutant, contains remarkable abilities which relate to an unreported genetic mutation.
The case, published in the British Journal of Anesthesia, could open the door for a host of new treatments to help people recover from surgery, manage chronic pain and anxiety disorders.
Jo’s super abilities caught attention of the doctors at the age of 65 when she needed a replacing of her severe arthritic hip problem.
Alongside her extensive medical history, the authors said: “She reported numerous burns and cuts without pain, often smelling her burning flesh before noticing any injury, and these wounds healed quickly with little or no residual scar.”
In tests she could also eat fiery Scotch bonnet chilies “without any discomfort, but a short-lasting ‘pleasant glow’ in her mouth”.
“I had no idea until a few years ago that there was anything that unusual about how little pain I feel, I just thought it was normal," Ms. Cameron said.
"Learning about it now fascinates me as much as it does anyone else.”
Pain geneticists at University College London and the University of Oxford identified two mutations; one in a gene called Faah (Fatty Acid Amide Hydrolase), which is well known to pain researchers and “junk DNA” which they dubbed “Faah-Out”, controls the Faah gene and in Ms Cameron switches it off.
The FAAH gene plays a role in the body’s endocannabinoid system, the parts of the central nervous system which play a role in pain, memory and mood and which the compounds in cannabis act on.
They also found a second gene, which had previously been written off as “junk DNA” with no useful purpose. It now appears this gene, which they dubbed “Faah-Out”, controls the Faah gene and in Ms. Cameron switches it off.
As well as her wound healing and pain insensitivity the woman scored a zero in tests of anxiety and depression, and said she never panics in dangerous situations like in a recent car accident.
If there is any kryptonite (apart from occasionally smelling your own sizzling flesh) it is that she was moderately absent minded and has always been prone to forgetting keys or losing her train of thought.
“The implications for these findings are immense,” said Dr Devjit Srivastava, the Raigmore pain consultant who diagnosed her.
Half of patients recovering from surgery still experience moderate to severe pain, despite modern painkillers.
It could be the case that the Faah-Out gene is the key to unlocking the pain reducing potential of the Faah gene where other attempts have failed.
“The findings point towards a novel pain killer discovery that could potentially offer post-surgical pain relief and also accelerate wound healing,” Dr Srivastava said.
“We hope this could help the 330 million patients who undergo surgery globally every year.”
Ms Cameron said she would "be elated if any research into my own genetics could help other people who are suffering,”
There could be many more people living with this mutation unnoticed and they appealed for more people to come forward as it could help drive these research efforts on.
